Predictors of Enrolment in a Transoral Surgical Trial for HPV-Related Oropharyngeal Carcinoma.
Nina Gallo, Caroline Casey, Andrea Costantino et al.
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In 30 seconds
This Phase III clinical trial investigated factors influencing enrolment in a transoral surgical trial for HPV-related oropharyngeal carcinoma. Among 51 eligible patients, 29 (57%) chose to participate. Key predictors included prior trial experience and perceptions of vulnerability, highlighting the importance of addressing patient concerns to improve trial participation.
Key findings
- 57% of eligible patients enrolled in the trial.
- Prior trial experience was a significant predictor of enrolment (p = 0.022).
- Not feeling like a 'guinea pig' also significantly influenced enrolment (p = 0.047).
- Travel distance showed a trending association with enrolment (p = 0.087).
Why it matters
Understanding the factors that influence patient enrolment in clinical trials is crucial for improving participation rates. By addressing concerns and enhancing comprehension, clinicians can help facilitate more equitable access to innovative treatments for patients with oropharyngeal carcinoma.