Non-invasive brain stimulation increases default mode network functional connectivity in a patient with Posterior Cortical Atrophy.
Thiago Paranhos, Anna Du, Ryan Eckbo et al.
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Case in brief
A patient with Posterior Cortical Atrophy (PCA) and memory impairments underwent individualized intermittent theta burst stimulation (iTBS) targeting the left caudal middle frontal gyrus. The intervention successfully increased functional connectivity with the default mode network. While associative memory performance did not improve, there were notable enhancements in visuospatial working memory, suggesting potential benefits of rTMS in PCA management.
Diagnostic / clinical pearl
This case highlights the potential of individualized rTMS to enhance functional connectivity in PCA, even when associative memory does not improve.
Why it matters
The findings suggest that rTMS may have specific benefits for visuospatial working memory in atypical Alzheimer's disease, warranting further investigation in clinical trials.