Hemostatic Efficacy and Safety of the Hybrid Injector ClearCoajet in Endoscopic Mucosal Resection of Large Colorectal Polyps: A Multicenter Randomized Trial.
Dig Dis SciAug 18, 2026 (epub)
Youngkyeong Nam, Han Hee Lee, Jin Lee et al.
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In 30 seconds
This multicenter randomized trial evaluated the hemostatic efficacy and safety of the ClearCoajet device during endoscopic mucosal resection of large colorectal polyps in 220 patients. The hemostasis success rate was 96.4% in the Coajet group compared to 84.0% in the control group, although the difference was not statistically significant (P = 0.176).
Key findings
- IPB occurred in 24.1% of EMR procedures, mostly mild cases.
- Hemostasis success rate was 96.4% in the Coajet group vs 84.0% in the control group.
- The risk difference in hemostasis success was 12.4 percentage points (95% CI, -4.7 to 31.3).
- No significant differences were found in hemostasis time or delayed bleeding between groups.
Why it matters
Understanding the effectiveness of new hemostatic devices like ClearCoajet can enhance procedural safety during endoscopic mucosal resections, potentially reducing complications associated with intraprocedural bleeding.
What to keep in mind
The study had a smaller-than-planned sample size, which may affect the robustness of the findings.