The efficacy of non-invasive brain stimulation interventions in obsessive-compulsive disorder management: A network meta-analysis of randomized controlled trials.
Hui Chen, Rui Gu, Xiaohan Jia et al.
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In 30 seconds
This network meta-analysis evaluated the efficacy of non-invasive brain stimulation (NIBS) interventions for obsessive-compulsive disorder (OCD) in 1456 participants across 42 randomized controlled trials. The analysis found that several NIBS protocols significantly reduced Yale-Brown Obsessive Compulsive Scale (Y-BOCS) scores, with high-frequency rTMS over FzFCz showing a mean difference of -11.77 compared to sham stimulation.
Key findings
- High-frequency rTMS over FzFCz reduced Y-BOCS scores by a mean difference of -11.77.
- Low-frequency rTMS over F3F4 showed a mean difference of -9.93 in Y-BOCS scores.
- High-frequency deep rTMS over FzFCz resulted in a standardized mean difference of -1.24 for depressive symptoms.
- High-frequency deep rTMS over FzFCz also produced a standardized mean difference of -1.88 for anxiety scores.
Why it matters
The findings suggest that specific NIBS protocols can serve as effective adjunctive treatments for OCD, potentially improving patient outcomes. Understanding the most effective parameters can guide clinicians in optimizing treatment strategies for this challenging condition.