Clinical Efficacy of Neurorrhaphy in Anterolateral Thigh Flap Reconstruction for Tongue Cancer Defects: A Randomized Controlled Trial.
Ann Surg OncolAug 19, 2026 (epub)
Peijing Ye, Jinhui Rao, Tao Xie et al.
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In 30 seconds
This randomized controlled trial evaluated the efficacy of nerve anastomosis in anterolateral thigh (ALT) flap reconstruction for tongue cancer defects in 40 patients. The N-ALT group, which received nerve anastomosis, demonstrated significantly improved sensory recovery, speech, and swallowing functions compared to the ALT group, with better quality of life outcomes reported at 2, 6, and 12 months post-surgery.
Key findings
- The N-ALT group showed significantly better sensory recovery compared to the ALT group (p < 0.05).
- Speech and swallowing functions were superior in the N-ALT group at all follow-up intervals.
- Patients in the N-ALT group reported better quality of life, particularly in emotional and swallowing domains.
- Flap volume analysis indicated less atrophy in the N-ALT group.
Why it matters
Enhancing functional recovery in patients undergoing reconstruction for tongue cancer is crucial for improving their quality of life. This study suggests that incorporating nerve anastomosis may lead to better sensory and functional outcomes.