Emergent Reversal of Intracranial Hemorrhage Using 4-Factor Prothrombin Complex Concentrate in a Pediatric Patient.

J Pediatr Hematol OncolAug 19, 2026 (epub)
Case ReportPediatricsHematology

Ruchi P Jain, Keri Bicking, Amanda Clouser

✦ AI-curated · Sources linked

Case in brief

An 11-year-old male with sinusitis complicated by multifocal intracranial abscesses and a superior sagittal sinus thrombus was treated with rivaroxaban. He presented with an intracranial hemorrhage requiring urgent craniotomy. The anticoagulant was reversed using 2223 units of 4-factor prothrombin complex concentrate (4F-PCC), approximately 45 units/kg. The patient did not experience any thromboembolic events in the following three months.

Diagnostic / clinical pearl

This case highlights the potential use of 4-factor prothrombin complex concentrate for reversing direct oral anticoagulants in pediatric patients with intracranial hemorrhage.

Source

PubMed · PMID 42616581

Published in J Pediatr Hematol Oncol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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