Fasting plasma amino acid profiles after resistance exercise with or without nutritional supplementation in older adults: an exploratory analysis of secondary outcomes from a randomized controlled trial.
Koichiro Sumi, Satoshi Seino, Miki Narita et al.
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In 30 seconds
This randomized controlled trial investigated fasting plasma amino acid profiles in community-dwelling older adults undergoing a 12-week resistance exercise program, with or without protein and micronutrient supplementation. Results indicated that while total amino acid concentrations decreased in both groups, the ExPM group experienced less decrease in leucine and phenylalanine compared to the Ex group, highlighting the impact of nutritional supplementation on amino acid metabolism.
Key findings
- Total, essential, and non-essential amino acid concentrations generally decreased from baseline to post-intervention in both groups.
- Leucine and phenylalanine showed significant group-by-time interactions, with greater decreases in the Ex group than in the ExPM group.
- The global arginine bioavailability ratio (GABR) increased significantly in both groups, particularly among those with lower baseline values.
- Glutamine-related ratios increased in the Ex group but remained largely unchanged in the ExPM group.
Why it matters
Understanding the metabolic changes in amino acid profiles following resistance exercise and nutritional supplementation can inform strategies to optimize muscle health in older adults, potentially enhancing recovery and overall physical function.