Second umbilical cord blood transplantation for relapsed adverse-risk acute myeloid leukemia patient with near-homozygous HLA haplotypes.

Transpl ImmunolAug 19, 2026 (epub)
Case ReportHematologyOncology (Medical)

Ke Wang, Fei Wang, Ye Jin et al.

✦ AI-curated · Sources linked

Case in brief

A patient with adverse-risk acute myeloid leukemia (AML) and near-homozygous HLA haplotypes underwent double units unrelated umbilical cord blood transplantation (dUCBT) twice. After molecular relapses at one and two years post-first transplant, complete remission was achieved with venetoclax and azacitidine. A second transplant was performed after a hematologic relapse three years later, leading to clinical stability for one year without graft-versus-host disease.

Diagnostic / clinical pearl

This case illustrates the feasibility of a second umbilical cord blood transplantation in relapsed adverse-risk AML patients with near-homozygous HLA haplotypes.

Source

PubMed · PMID 42617955

Published in Transpl Immunol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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