Effects of diabetes, obesity, and metabolic syndrome on alcohol-associated liver disease: A systematic review.
Dhiraj K Peddu, Vitchapong Prasitsumrit, Matthew J Kubina et al.
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In 30 seconds
This systematic review evaluated the impact of cardiometabolic risk factors (CMRFs) on clinical outcomes in adults with alcohol-associated liver disease (ALD). Analyzing 19 studies with 132,054 patients, it found that diabetes significantly increased overall mortality (adjusted hazard ratio 3.00) and liver-related mortality (aHR 3.60), while obesity and metabolic syndrome also worsened outcomes.
Key findings
- Diabetes was linked to aHR 3.00 for overall mortality and aHR 3.60 for liver-related mortality.
- Elevated BMI correlated with aHR 1.16-1.58 for all-cause mortality and aHR 3.76 for cardiovascular mortality.
- Metabolic syndrome increased overall mortality risk (HR 1.27-2.37) and liver-related mortality (HR 1.47-2.06).
- A higher burden of CMRFs was associated with lower transplant-free survival.
Why it matters
Understanding the influence of diabetes, obesity, and metabolic syndrome on ALD outcomes is crucial for risk stratification and management. Clinicians can better identify patients at higher risk for severe complications and mortality, guiding more tailored interventions.