First Moroccan ABO-Incompatible Living Donor Kidney Transplantation: Successful Desensitization Without Intravenous Immunoglobulin.
Mohamed Amine Khalfaoui, Sara Dehayni, Rokia Khadouri et al.
✦ AI-curated · Sources linked
Case in brief
A 23-year-old woman with end-stage kidney disease due to congenital uropathy received a kidney transplant from her mother, despite ABO incompatibility (donor B+, recipient O+). The desensitization protocol included rituximab and plasma exchange, without intravenous immunoglobulins. Post-transplant, the patient exhibited immediate graft function, stable serum creatinine, and no complications or rejection during one year of follow-up.
What made this case unusual
This case is notable for successfully performing ABO-incompatible kidney transplantation in Morocco using a simplified desensitization protocol that did not involve intravenous immunoglobulins.
Diagnostic / clinical pearl
Clinicians should consider that ABO-incompatible kidney transplantation can be safely performed with effective desensitization strategies, even in settings with limited resources.
Why it matters
This case highlights the potential for expanding access to kidney transplantation in developing countries by utilizing simplified protocols that reduce costs and complexity.