Standardized small black soybean extract improves tear film stability and dry eye-related symptoms: a 12 week randomized placebo-controlled trial.
Food FunctSep 21, 2026 (epub)
Clinical ResearchOphthalmology
Yoonhee Lee, Hyungbin Hwang, Juyeon Park et al.
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In 30 seconds
This 12-week randomized, double-blind, placebo-controlled trial evaluated the effects of standardized small black soybean extract (SSBS) on tear film stability and dry eye symptoms in 100 adults. SSBS significantly improved tear film break-up time (TBUT) compared to placebo (+0.35 ± 1.54 vs. -0.33 ± 1.46 s; p = 0.0457), indicating potential benefits for dry eye management.
Key findings
- SSBS improved TBUT by +0.35 ± 1.54 seconds compared to -0.33 ± 1.46 seconds in the placebo group (p = 0.0457).
- The OSDI total score decreased by -22.41 ± 23.16 with SSBS versus -12.65 ± 14.59 with placebo (p = 0.0252).
- Significant improvements were noted in the ocular symptoms subscale for SSBS compared to placebo.
Why it matters
The findings suggest that SSBS may enhance tear film stability and reduce dry eye symptoms, which is important for improving patient comfort and quality of life in those affected by dry eye disease.