Adjunctive psychobiotic Lactiplantibacillus plantarum PS128 ameliorates gastrointestinal comorbidities and alters circulating miRNAs and gut microbiota in children with Tourette syndrome: a randomized controlled trial.

In 30 seconds

This randomized controlled trial evaluated the effects of the psychobiotic Lactiplantibacillus plantarum PS128 on children aged 4-18 with Tourette syndrome. While the primary outcome of tic severity did not differ significantly between groups, the PS128 group showed significant improvements in gastrointestinal symptoms, particularly upper abdominal pain, and trends toward better attention performance. Seventy-three participants completed the study.

Key findings

• The PS128 group had significant reductions in gastrointestinal symptoms, especially upper abdominal pain.
• No significant difference in tic severity was observed between the PS128 and placebo groups.
• Eight differentially expressed miRNAs were identified post-intervention, linked to nervous system development.
• Increased Lactiplantibacillus abundance correlated positively with miR-199a-3p expression.

Why it matters

Understanding the role of gut microbiota and miRNA in Tourette syndrome may open new avenues for adjunctive therapies. Improved gastrointestinal symptoms can enhance overall quality of life for affected children.