METASTATIC UROTHELIAL CARCINOMA OF THE BLADDER TO THE RETINA: A CLINICOPATHOLOGIC CORRELATION AND REVIEW OF THE LITERATURE.
Nicholas M Mueller, Cory A Christensen, Elias M Mullane et al.
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Case in brief
A patient with urothelial carcinoma of the bladder had a large yellow-white lesion in the superotemporal retina of the left eye. Fluorescein angiography showed vitreous-debris blockage, punctate hyperfluorescence, patchy capillary nonperfusion, hemorrhagic blockage, and late central leakage. Vitreous cytology identified atypical cells, and retinal biopsy showed invasive carcinoma. The tumour cells were immunoreactive for high molecular weight cytokeratin, uroplakin III, and GATA-3, and negative for CK20, supporting urothelial origin. The report describes the lesion as retinal metastasis from bladder urothelial carcinoma; the abstract does not state its subsequent clinical course or resolution.
What made this case unusual
The report describes a retinal metastasis from bladder urothelial carcinoma, confirmed by retinal biopsy and immunohistochemistry; the authors identified it as the second documented case to their knowledge.
Diagnostic / clinical pearl
When a retinal lesion occurs in a patient with bladder urothelial carcinoma, biopsy with immunohistochemistry can establish metastatic urothelial origin; the reported tumour was positive for uroplakin III and GATA-3 and negative for CK20.