Multifocal Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type, Presenting on Face and Chest: Complete Remission With R-CHOP.
Michael Panagiotidis, Iclal Gerdemeli, Nikolaos Chaitidis et al.
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Case in brief
A 79-year-old woman developed rapidly enlarging erythematous-to-violaceous tumors and plaques on her face, chest, left upper arm, and upper back. Histopathology and immunohistochemistry confirmed primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT). She received six cycles of R-CHOP and achieved complete remission, with no relapse during 1.5 years of follow-up.
What made this case unusual
PCDLBCL-LT, which predominantly affects the lower extremities, presented at multiple non-leg sites, including the face and chest.
Diagnostic / clinical pearl
Consider PCDLBCL-LT in the differential diagnosis of rapidly enlarging cutaneous tumors even when lesions are confined to non-leg sites; confirmation in this case relied on histopathology and immunohistochemistry.