Protein requirements and determinants of protein catabolic rate in critically ill patients with acute kidney injury: A post hoc analysis of the ENGINE randomized controlled trial.
Clin Nutr ESPENAug 21, 2026 (epub)
Wankawee Jeerangsapasuk, Aphichat Chatkrailert
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In 30 seconds
This post hoc analysis of the ENGINE randomized controlled trial evaluated protein requirements in 78 critically ill patients with acute kidney injury (AKI). The study found a mean protein catabolic rate (PCR) of 1.15 ± 0.42 g/kg/day. Patients receiving 0.8-1.2 g/kg/day of protein intake had a lower risk of 28-day mortality compared to those receiving less than 0.8 g/kg/day (adjusted HR 0.29).
Key findings
- Mean protein catabolic rate was 1.15 ± 0.42 g/kg/day.
- Body weight and blood urea nitrogen were independently associated with PCR.
- Patients receiving 0.8-1.2 g/kg/day protein had a lower risk of 28-day mortality (adjusted HR 0.29).
- No significant difference in protein intake between survivors and non-survivors at 28 days.
Why it matters
Understanding protein requirements in critically ill patients with AKI is crucial for optimizing nutritional support and potentially improving clinical outcomes. This study provides insights into individualized protein prescriptions based on PCR.