Antitumor activity of scorpion venom-derived peptides: A meta-analysis of preclinical studies.
Pharmacol ResAug 22, 2026 (epub)
Clinical ResearchOncology (Medical)
Lucero A Hernández-Carrizales, Alexa Hernández-Hernández, Jorge L Díaz-Gómez et al.
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In 30 seconds
This meta-analysis evaluated the antitumor effects of scorpion venom-derived peptides (SVDPs) across various cancer types in preclinical studies. A total of 27 articles were analyzed, revealing that SVDPs significantly reduced cell viability, particularly in lung cancer cells (IC 50 pooled mean: 12.69 μM; 95% CI: 5.80-19.57) and induced early apoptosis (SMD: 5.11; 95% CI: 2.54-7.68).
Key findings
- SVDPs reduced cell viability in cancer cells, with a greater effect on lung cancer cells (IC 50 pooled mean: 12.69 μM; 95% CI: 5.80-19.57).
- SVDPs induced early apoptosis with a standardized mean difference of 5.11 (95% CI: 2.54-7.68).
- SVDPs reduced tumor volume in animal models (SMD = -7.29; 95% CI: -12.73 to -1.85).
Why it matters
Understanding the antitumor activity of SVDPs could lead to the development of novel cancer therapies that are more effective and selective, addressing current limitations in cancer treatment.