Manuka Honey Sinus Irrigation Versus Systemic Itraconazole in Allergic Fungal Rhinosinusitis: Randomised Clinical Trial for Efficacy and Safety.
Khalaf Hamead, Mostafa Ismail, Abdelrahim A Abdelkarim et al.
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In 30 seconds
This randomized clinical trial evaluated the efficacy of Manuka honey sinus irrigation versus oral itraconazole in 30 patients with allergic fungal rhinosinusitis (AFRS) post-endoscopic sinus surgery. Results indicated that Manuka honey significantly improved Lund-Kennedy endoscopic scores, total IgE levels, and SNOT-22 scores compared to itraconazole, suggesting it may be a more effective postoperative treatment for AFRS.
Key findings
- Manuka honey sinus irrigation significantly improved Lund-Kennedy endoscopic scores compared to itraconazole.
- Total IgE levels were significantly reduced in the Manuka honey group.
- SNOT-22 scores showed significant improvement in patients receiving Manuka honey.
- Both treatment groups had similar Lund-Mackay radiological scores and postoperative infection rates.
Why it matters
The findings suggest that Manuka honey sinus irrigation may offer a safer and more effective alternative to systemic antifungals like itraconazole for managing postoperative symptoms in patients with AFRS, potentially reducing systemic side effects.