Subconjunctival Botulinum Toxin-A Injection as a Treatment for Neuropathic Corneal Pain.
Michael Christensen, Donald R Nixdorf, Wassef Chanbour
✦ AI-curated · Sources linked
Case in brief
Two patients with chronic neuropathic corneal pain unresponsive to standard treatments received perilimbal subconjunctival injections of botulinum toxin type A. Patient 1 required dose escalation to achieve pain relief, while Patient 2 responded to a single injection. Both patients reported significant pain reduction and decreased corneal sensitivity within two weeks, although relief diminished after approximately three months. Minor self-limited adverse events were noted.
Diagnostic / clinical pearl
Subconjunctival botulinum toxin type A injections can be an effective adjunctive treatment for refractory neuropathic corneal pain, particularly when conventional therapies fail.
Why it matters
This case highlights a novel technique that may provide relief for patients suffering from chronic pain conditions of the cornea, warranting further investigation into its efficacy and safety.