Diurnal differences in the effects of heat exposure on renal function: A randomized controlled crossover trial.
Jintao Liu, Yuefang Li, Yarui Fan et al.
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In 30 seconds
This randomized controlled crossover trial investigated the effects of heat exposure on renal function in 41 healthy adults. Participants were exposed to heat during the day (32°C) and night (30°C) compared to thermoneutral conditions (26°C). Results showed that daytime heat increased blood markers of glomerular filtration, while nighttime heat elevated urinary biomarkers of kidney stress, indicating distinct diurnal patterns in renal responses.
Key findings
- Daytime heat exposure increased creatinine by 7.67% and cystatin C by 3.05%.
- Estimated glomerular filtration rate decreased by 0.05% during daytime heat exposure.
- Nighttime heat exposure elevated insulin-like growth factor-binding protein 7 by 58.40%.
- Increases in insulin-like growth factor-binding protein 7 were significantly greater at night.
Why it matters
Understanding the diurnal differences in renal responses to heat exposure is crucial for clinicians, especially as climate change increases nighttime heat. This knowledge can inform patient management and preventive strategies for kidney injury in vulnerable populations.