Association Between Diaphragm Ultrasound Measures and Extubation Outcomes in Neonates: A Systematic Review and Meta-Analysis.
Mayson L A Sousa, Eleonora Balzani, Sebastian Dubo et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the relationship between diaphragm ultrasound measures and extubation outcomes in mechanically ventilated neonates. Among 255 neonates, extubation failure occurred in 35%. The study found that those who failed extubation had a significantly lower diaphragm thickening fraction (MD = -9.51%; 95% CI: -14.73 to -4.29; p = 0.0004) compared to those who were successfully extubated.
Key findings
- Extubation failure occurred in 90 out of 255 neonates (35%).
- Neonates who failed extubation had a diaphragm thickening fraction lower by 9.51% compared to those who succeeded.
- Differences in diaphragm thickness and excursion were not statistically significant.
- Overall risk of bias in the studies was moderate to high.
Why it matters
Understanding the association between diaphragm function and extubation outcomes can help clinicians assess the readiness for extubation in neonates, potentially improving patient management and outcomes.
What to keep in mind
The overall risk of bias was moderate to high, mainly due to inadequate adjustment for confounding factors and variability in outcome definitions.