Gut microbial diversity at baseline conditions the clinical, microbiome, and metabolic response to paraprobiotic Lactiplantibacillus plantarum LRCC5282 in overweight adults.
Gut MicrobesAug 25, 2026 (epub)
Ahyoung Lim, Sunghan Kim, Woongkwon Kwak et al.
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In 30 seconds
This randomized controlled trial investigated the impact of baseline gut microbial diversity on the response to the paraprobiotic Lactiplantibacillus plantarum LRCC5282 in 120 overweight adults over 12 weeks. The study found that participants with low gut microbial diversity experienced significant reductions in body weight, body mass index, and leptin levels, while those with high diversity showed no consistent response.
Key findings
- In the low-diversity subgroup, LP5282-P led to significant reductions in body weight and body mass index.
- Circulating leptin levels decreased significantly in the low-diversity subgroup after LP5282-P treatment.
- Fecal metabolite profiles showed elevated acetate and butyrate concentrations in the low-diversity group.
- High-diversity subgroup exhibited no consistent response across clinical outcomes.
Why it matters
Understanding the role of gut microbial diversity in treatment responsiveness can help tailor microbiota-targeted interventions for obesity management, potentially improving clinical outcomes in specific patient populations.