Myelin Oligodendrocyte Glycoprotein Antibodies in Breast Milk in a Lactating Woman With Severe Enterovirus-Associated MOGAD.
Stefan Kammermeier, Suzette Heck, Hanna Zimmermann et al.
✦ AI-curated · Sources linked
Case in brief
A 38-year-old lactating woman presented with severe MOGAD following enterovirus gastroenteritis. She developed a rapid decline into coma with status epilepticus, necessitating intensive care. High serum MOG-IgG levels were identified, and treatment with high-dose glucocorticosteroids and plasma exchange resulted in significant clinical improvement. MOG-IgG was found in her breast milk, but not in her infant's serum.
What made this case unusual
This case highlights the presence of MOG-IgG in breast milk, a finding not previously reported, raising questions about potential maternal-infant transmission.
Diagnostic / clinical pearl
Clinicians should consider MOGAD in patients with severe CNS inflammation following viral infections, and recognize the importance of early intervention.
Why it matters
Understanding the presence of MOG-IgG in breast milk may inform future studies on maternal antibody transmission and its implications for breastfeeding infants.