Effectiveness of a digital cognitive behavioral therapy application for vasomotor symptoms in menopausal women: An open-label pilot randomized controlled trial.
MaturitasAug 21, 2026 (epub)
Clinical ResearchObstetrics & Gynecology
Petra Stute, Elena Pavicic, Kai Schulze-Wundling et al.
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In 30 seconds
This open-label pilot randomized controlled trial evaluated the effectiveness of a digital cognitive behavioral therapy application for managing vasomotor symptoms in menopausal women. Among 100 participants, the intervention group showed a significant reduction in hot flush problem ratings, with an adjusted mean change of -2.68 compared to -1.21 in the control group (p < 0.001).
Key findings
- The intervention group had a mean change of -2.68 in hot flush ratings compared to -1.21 in the control group.
- 70.8% of participants in the intervention group achieved a clinically meaningful reduction of at least two points.
- No serious adverse events were reported; only 5.9% experienced device-related events.
Why it matters
The study highlights the potential of digital cognitive behavioral therapy as a non-pharmacological approach to alleviate bothersome menopausal symptoms, which can significantly impact quality of life for many women.