Closed-loop insulin delivery for glycaemic control in hospitalised and perioperative adults: A systematic review and meta-analysis of randomised controlled trials.

In 30 seconds

This systematic review and meta-analysis evaluated the impact of closed-loop insulin delivery on glycaemic control in hospitalised and perioperative adults. Analyzing data from seven randomised controlled trials with 375 participants, the study found that closed-loop insulin delivery increased time in the target glucose range by 23.91 percentage points and reduced mean glucose by 1.79 mmol/L, with moderate certainty for both outcomes.

Key findings

• Closed-loop insulin delivery increased time in target glucose range by 23.91 percentage points.
• Mean glucose levels were reduced by 1.79 mmol/L with closed-loop insulin delivery.
• No severe hypoglycaemic events occurred in either group during the trials.
• Evidence for clinically significant hyperglycaemia was exploratory and imprecise.

Why it matters

Improving glycaemic control in hospitalised patients is crucial for reducing complications and enhancing recovery. This study suggests that closed-loop insulin delivery may offer a more effective approach compared to conventional methods.