Chromosomally normal twin pregnancy following transfer of euploid and chaotic embryos, including those with trisomy 21.
Ting-Chi Huang, Mei-Zen Huang, Jiann-Loung Hwang et al.
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Case in brief
A 35-year-old woman with recurrent implantation failure underwent IVF with preimplantation genetic testing for aneuploidy, resulting in the transfer of one euploid female embryo and one chaotic male embryo with multiple aneuploidies, including trisomy 21. Despite recommendations against transferring the chaotic embryo, the couple proceeded. A dichorionic diamniotic twin pregnancy was confirmed, and healthy twins were delivered at 35 weeks and 4 days, both with normal karyotypes.
Diagnostic / clinical pearl
Clinicians should be aware that some chaotic embryos may still lead to viable pregnancies, despite their aneuploidy status.
Why it matters
This case underscores the complexities of embryo selection in IVF and the potential for unexpected outcomes, warranting further investigation into the management of chaotic embryos.