Impact of Frailty on Activities of Daily Living in Hospitalized Older Adults: A Systematic Review and Meta-Analysis.

Geriatr Gerontol IntSep 1, 2026
Clinical ResearchGeriatricsOpen access

Tomohiko Kamo, Ryoma Asahi, Yasuko Inaba et al.

✦ AI-curated · Sources linked

In 30 seconds

This systematic review and meta-analysis examined the impact of frailty on activities of daily living (ADL) and clinical outcomes in hospitalized adults aged 65 and older. The analysis of 57 cohort studies revealed that frailty is significantly associated with worse ADL status (SMD -1.04) and increased mortality risk (RR 2.26).

Key findings

  • Frailty was linked to worse ADL status with a standardized mean difference of -1.04.
  • Frail patients had a 2.26 times higher risk of mortality compared to non-frail patients.
  • Frail individuals were less likely to be discharged home (RR 0.79).
  • The risk of 30-day readmission was 1.47 times higher in frail patients.

Why it matters

Understanding the association between frailty and adverse outcomes in hospitalized older adults can help clinicians identify high-risk patients and tailor interventions to improve their care and discharge planning.

What to keep in mind

Substantial heterogeneity and potential residual confounding were noted, which may affect the interpretation of results.

Source

PubMed · PMID 42642794Free full text on PubMed Central

Published in Geriatr Gerontol Int. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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