Clinical Trial: Intensive Supervised Nutritional Therapy Versus Guideline-Based Nutritional Advice for Sarcopenia in Decompensated Cirrhosis-A Randomised Controlled Trial.
Gireesh Kumar Dhaked, Prabhat Narain Sharma, Kamlesh Kumar Sharma et al.
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In 30 seconds
This randomized controlled trial evaluated the effectiveness of dietitian-supervised intensive nutritional therapy versus physician-led guideline-based dietary advice in 180 patients with decompensated cirrhosis and sarcopenia. The study found that dietitian-supervised therapy significantly improved skeletal muscle index by +2.50 cm²/m² and handgrip strength in both men (+7.5 kg) and women (+4.8 kg), along with enhanced gait velocity (+0.23 m/s).
Key findings
- Dietitian-supervised therapy improved skeletal muscle index by +2.50 cm²/m² compared to physician-led care.
- Handgrip strength increased by +7.5 kg in men and +4.8 kg in women with dietitian supervision.
- Gait velocity improved by +0.23 m/s with intensive nutritional therapy.
- 68.9% of participants showed an overall multidomain response with dietitian supervision versus 37.8% with physician-led advice.
Why it matters
The findings highlight the importance of specialized nutritional interventions in managing sarcopenia among patients with decompensated cirrhosis, potentially leading to better physical outcomes and quality of life.