Stereotactic body radiation therapy for hepatocellular carcinoma larger than 5 cm: a systematic review and meta-analysis.

Jpn J RadiolAug 26, 2026 (epub)
Clinical ResearchOncology (Medical)Radiology (Diagnostic)

Jiaoling He, Xiurong Wang, Tingfang Zuo et al.

✦ AI-curated · Sources linked

In 30 seconds

This systematic review and meta-analysis assessed stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC) ≥ 5 cm, including eleven studies and 424 patients. Pooled local control was 81% (95% CI, 66-90%) at 1 year and 69% (95% CI 48-84%) at 2 years; corresponding overall survival was 60% (95% CI 55-66%) and 37% (95% CI 30-45%). Severe liver toxicity (grade ≥ 3) was reported as rare. The authors consider SBRT a viable option, while noting the need for further prospective studies.

Key findings

  • Pooled local control rates were 81% (95% CI, 66-90%) at 1 year and 69% (95% CI 48-84%) at 2 years.
  • Pooled overall survival rates were 60% (95% CI 55-66%) at 1 year and 37% (95% CI 30-45%) at 2 years.
  • Mean/median age < 65 years was associated with more favorable 2-year overall survival (P < 0.05).
  • Severe liver toxicity (grade ≥ 3) was described as rare.

Why it matters

Large HCC can be challenging to treat, and these pooled results provide an estimate of local control, survival, and severe liver toxicity after SBRT in this population. They may help frame discussion of SBRT as a treatment option, while the evidence remains based on included studies rather than establishing comparative benefit.

What to keep in mind

The review included eleven studies and 424 patients; the abstract does not report prospective comparative evidence, and the authors state that further prospective studies are warranted.

Source

PubMed · PMID 42645788

Published in Jpn J Radiol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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