Exercise with motor cortex high-definition transcranial direct current stimulation enhances cardiovascular efficiency and lower-limb function in multiple sclerosis: A crossover, double-blind, and proof-of-principle study.
Arthur R Chaves, Aidan Peters, Kai Curbelo-Torrejon et al.
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In 30 seconds
This crossover randomized controlled trial investigated the effects of exercise combined with high-definition transcranial direct current stimulation (HD-tDCS) in individuals with Multiple Sclerosis (MS). The study found that cardiovascular efficiency, measured by the heart rate-to-work rate ratio, significantly improved during exercise with HD-tDCS compared to exercise alone, particularly in older participants (p=0.010).
Key findings
- Cardiovascular efficiency improved significantly during exercise+HD-tDCS compared to exercise alone (p=0.010).
- Both groups increased walking speed only after exercise+active HD-tDCS.
- SDMT scores declined immediately post HD-tDCS alone and during exercise+active HD-tDCS (p<0.05).
Why it matters
The findings suggest that combining exercise with HD-tDCS may enhance cardiovascular outcomes in MS patients, highlighting the potential for tailored neuromodulation strategies in neurorehabilitation. Understanding these effects can guide clinicians in optimizing rehabilitation approaches for individuals with MS.