Cytological Identification of a Rhabdoid Variant of Pancreatic Neuroendocrine Neoplasm.
Miyu Okuda, Keishi Mizuguchi, Tatsuya Mori et al.
✦ AI-curated · Sources linked
Case in brief
A 48-year-old woman presented with an incidental pancreatic head mass. Cytological analysis from endoscopic ultrasound-guided fine-needle aspiration revealed tumor cells with eccentric nuclei and prominent eosinophilic intracytoplasmic inclusions. Immunocytochemistry confirmed the diagnosis of a rhabdoid variant of pancreatic neuroendocrine neoplasm, highlighting the potential for cytological identification of this rare variant.
What made this case unusual
This case is notable for being the first reported instance of a rhabdoid-type pancreatic neuroendocrine tumor diagnosed solely through cytology.
Diagnostic / clinical pearl
Clinicians should recognize that distinctive intracytoplasmic inclusions in cytology samples can indicate a rhabdoid variant of pancreatic neuroendocrine neoplasm.
Why it matters
Awareness of this rare phenotype enhances diagnostic accuracy and contributes to a better understanding of the clinicopathological spectrum of pancreatic neuroendocrine tumors.