Association of computed tomography-derived body composition and complications after radical gastrectomy for gastric cancer: A systematic review and meta-analysis.
Tiezhu Ren, Yue Peng, Long Ma et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the association between computed tomography-derived body composition parameters and postoperative complications (POCs) in gastric cancer patients. The analysis included 21 studies, revealing that sarcopenia, defined by skeletal muscle index (SMI), was significantly associated with increased POCs, with a pooled risk ratio of 2.73 (95% CI: 1.83-4.08).
Key findings
- Sarcopenia defined by skeletal muscle index (SMI) was significantly associated with POCs.
- The pooled risk ratio for sarcopenia and POCs was 2.73 (95% CI: 1.83-4.08).
- 21 studies were included in the meta-analysis, all providing adjusted effect estimates.
- Variability in measurement methods limited the strength of the evidence.
Why it matters
Understanding the role of body composition in predicting postoperative complications can enhance risk stratification in gastric cancer patients, potentially improving surgical outcomes and patient management.
What to keep in mind
Variability in measurement methods and outcome definitions limits the strength and clinical applicability of the findings.