Diagnostic accuracy of MRI and PSMA PET/CT for detection of histologically confirmed lymph node metastasis in prostate cancer: A systematic review.
Emeka Ihechi Udeh, Solomon Anyimba, Loius Okolie et al.
✦ AI-curated · Sources linked
In 30 seconds
This systematic review and meta-analysis evaluated the diagnostic accuracy of PSMA PET/CT and mpMRI for detecting histologically confirmed pelvic lymph node metastases in patients with intermediate- and high-risk prostate cancer. The analysis included 1,999 patients across 16 studies. PSMA PET/CT showed a pooled sensitivity of 54.6% and specificity of 92.7%, while mpMRI had a sensitivity of 33.0% and specificity of 94.9%.
Key findings
- PSMA PET/CT had a pooled sensitivity of 54.6% and specificity of 92.7%.
- mpMRI demonstrated a pooled sensitivity of 33.0% and specificity of 94.9%.
- The HSROC AUC for PSMA PET/CT was 0.909, while for mpMRI it was 0.941.
- Indirect comparison suggested PSMA PET/CT had higher sensitivity than mpMRI.
Why it matters
Understanding the diagnostic accuracy of imaging modalities for lymph node metastases is crucial for treatment planning in prostate cancer. The findings highlight the limitations of both PSMA PET/CT and mpMRI, particularly their moderate sensitivity, which may impact clinical decision-making.