Prevalence of epilepsy and seizures in frontotemporal dementia: a systematic review and meta-analysis.
Lucca Passow Carpinelli, João Pedro Sá Lins, Albert Abad Velazquez et al.
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In 30 seconds
This systematic review and meta-analysis examined the prevalence of epilepsy and seizures in individuals with frontotemporal dementia (FTD). Analyzing data from 11 studies involving 3,182 participants, the pooled prevalence was found to be 7% (95% CI, 4%-11%). The study highlights significant heterogeneity in prevalence across different clinical variants of FTD.
Key findings
- The pooled prevalence of epilepsy or seizures in FTD was 7% (95% CI, 4%-11%).
- Prevalence varied by clinical variant: 3% in behavioral-variant FTD and 9% in primary progressive aphasia.
- Increased odds of seizures in FTD compared to controls were suggested, with a ratio measure of 3.72 (95% CI, 1.38-10.06).
Why it matters
Understanding the prevalence of seizures in frontotemporal dementia is crucial for clinicians, as it can influence management strategies and patient care. Recognizing this aspect of FTD may lead to better monitoring and treatment of affected individuals.
What to keep in mind
Substantial heterogeneity and variable methodological quality among studies limit the reliability of the prevalence estimates.