Radiotherapy With Hyperthermia for Prostatic Ductal Adenocarcinoma: Primary and Salvage Cases.
Yasuaki Matsuura, Daisuke Nakaya, Subaru Tani et al.
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Case in brief
Three patients with prostatic ductal adenocarcinoma received radiotherapy combined with regional hyperthermia: two with locally advanced cT3aN0M0 disease received definitive intensity-modulated radiotherapy, and one with biochemical recurrence after prostatectomy received salvage three-dimensional conformal radiotherapy. Therapeutic heating was achieved in all three. Clinical control was maintained at follow-up of six, nine, and eight years, respectively. The salvage patient had a subsequent PSA increase, controlled with short-term hormonal therapy, with no later clinical progression.
What made this case unusual
The report describes durable clinical control after radiotherapy combined with regional hyperthermia in three patients with this aggressive histological variant, including both definitive and salvage treatment settings.
Diagnostic / clinical pearl
In prostatic ductal adenocarcinoma, the report illustrates that regional hyperthermia can be delivered alongside definitive or salvage radiotherapy, with therapeutic heating achieved in each case.