Successful Engraftment Following Second Cord Blood Transplantation After Graft Failure in a Child With Relapsed B-ALL.

Tokai J Exp Clin MedSep 6, 2026 (epub)
Case ReportHematologyPediatricsOncology (Medical)

Ryota Kaneko, Takashi Koike, Yukie Yokoyama et al.

✦ AI-curated · Sources linked

Case in brief

A 9-year-old boy with relapsed B-cell precursor acute lymphoblastic leukemia experienced primary graft failure after his first umbilical cord blood transplantation due to low CD34-positive cell dose and significant HLA mismatch. Following reduced-intensity conditioning, a second transplantation with a more compatible cord blood unit resulted in successful neutrophil engraftment by day +34 and stable donor chimerism, despite managing several post-transplant complications.

Diagnostic / clinical pearl

This case highlights the potential for successful salvage through a second umbilical cord blood transplantation after primary graft failure, particularly when improved donor compatibility and cell dose are prioritized.

Source

PubMed · PMID 42669944

Published in Tokai J Exp Clin Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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