Honey vs. pharmacological treatment for acute cough in children: a systematic review and meta-analysis of randomized controlled trials.
Mariana Timm Brun, Maria Clara Abreu Vianna Braga, Sabrine Teixeira Ferraz Grunewald
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In 30 seconds
This systematic review and meta-analysis evaluated the effectiveness of honey compared to pharmacological treatments for acute cough in children, analyzing data from 7 studies involving 576 patients. The primary analysis showed no significant differences in most outcomes, but honey significantly improved sleep quality in children (MD: -0.73; 95% CI: -1.45 to -0.01; p=0.05). Sensitivity analyses indicated potential benefits of honey across all outcomes.
Key findings
- Honey significantly reduced the impact of cough on child's sleep (MD: -0.73; 95% CI: -1.45 to -0.01; p=0.05).
- Post-hoc analyses suggested honey may improve cough frequency, severity, and bothersomeness.
- Subgroup analyses confirmed honey's consistent benefits regardless of pharmacological comparator.
- Honey showed significant benefits over dextromethorphan in two endpoints.
Why it matters
The findings suggest that honey may be a safe and effective alternative to pharmacological treatments for acute cough in children, addressing concerns about the risks associated with pediatric antitussives. This could influence prescribing practices in pediatric care.