The impact of unilateral endometriomas on ovarian response to stimulation: a systematic review and meta-analysis.
D R Kalaitzopoulos, M Zografou, A Daniilidis et al.
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In 30 seconds
This systematic review and meta-analysis examined the impact of unoperated unilateral endometriomas on ovarian response during stimulation cycles in women with endometriosis. The analysis included 13 studies and found that the number of oocytes retrieved from affected ovaries was comparable to unaffected ovaries (MD -0.72, 95% CI -1.45 to 0.02).
Key findings
- Oocytes retrieved from affected ovaries were comparable to unaffected ovaries (MD -0.72, 95% CI -1.45 to 0.02).
- The number of MII oocytes was similar between affected and unaffected ovaries (MD -0.60, 95% CI -1.86 to 0.66).
- Good-quality embryos were comparable between both groups (MD -0.18, 95% CI -0.53 to 0.18).
- The number of embryos formed was significantly lower in affected ovaries (MD -0.72, 95% CI -1.39 to -0.05).
Why it matters
Understanding the effects of unoperated endometriomas on ovarian response is crucial for optimizing fertility treatments. These findings may influence decisions regarding surgical intervention prior to assisted reproductive technologies.
What to keep in mind
Most studies included were observational and retrospective, increasing the risk of bias and inconsistent outcome reporting.