Polyphyllin I in malignant tumors: molecular mechanisms and advances.
PhytomedicineAug 26, 2026 (epub)
Clinical ResearchOncology (Medical)
Yiyan Zhai, Xiangli Yin, Zeyu Xue et al.
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In 30 seconds
This systematic review examines Polyphyllin I (PPI), a natural product from Rhizoma Paridis, focusing on its antitumor mechanisms and druggability. The review highlights PPI's ability to induce apoptosis, autophagy, and ferroptosis, while also suppressing tumor cell migration and reversing drug resistance. The findings underscore PPI's potential as a multi-target anticancer agent, although research is still in the preclinical phase.
Key findings
- PPI induces apoptosis and autophagy, contributing to its antitumor effects.
- It suppresses tumor cell migration, invasion, and epithelial-mesenchymal transition.
- PPI regulates oxidative stress and induces ferroptosis in cancer cells.
- The compound shows potential for reversing multidrug resistance and synergizing with chemotherapeutic agents.
Why it matters
Understanding the multi-target mechanisms of PPI can inform future cancer treatment strategies, particularly in developing combination therapies that enhance efficacy and overcome drug resistance.