Successful Control of Late-Onset Nephrotic Syndrome in FN1-Associated Fibronectin Glomerulopathy: A 17-Year Clinical Course.
Nobuhiro Kanazawa, Masayuki Iyoda, Kazuki Abe et al.
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Case in brief
A 26-year-old woman with fibronectin glomerulopathy (FNG) due to an FN1 variant developed nephrotic syndrome after 17 years of proteinuria. Initial supportive therapy was inadequate, leading to the initiation of prednisolone and cyclosporine A, resulting in partial remission. The addition of an SGLT2 inhibitor during immunosuppression tapering may have aided in maintaining remission.
Diagnostic / clinical pearl
This case highlights the potential effectiveness of immunosuppressive therapy in managing late-onset nephrotic syndrome associated with fibronectin glomerulopathy.
Why it matters
The findings suggest that SGLT2 inhibitors may play a role in maintaining remission in patients with nephrotic syndrome related to FNG, warranting further investigation.