The WNT/β-catenin Pathway and Matrix Metalloproteinase-9 in hypermobile Ehlers-Danlos Syndrome and Autism Spectrum Disorder: A Possible Connection.

In 30 seconds

This narrative review explores the connection between hypermobile Ehlers-Danlos Syndrome (hEDS) and Autism Spectrum Disorder (ASD), highlighting their symptom overlap and comorbidity. A systematic review indicated a joint hypermobility prevalence of 22.3% in autistic individuals, increasing to 31% with clinical assessment. The review discusses the WNT/β-catenin pathway and matrix metalloproteinases' roles in these disorders.

Key findings

• The prevalence of joint hypermobility in autistic individuals is 22.3%, rising to 31% with clinical assessment.
• The prevalence of Ehlers-Danlos Syndrome or Hypermobility Spectrum Disorder is 27.9%, increasing to 39% with clinical assessment.
• The review highlights the potential link between hEDS and ASD through WNT/β-catenin pathway dysregulation.

Why it matters

Understanding the connection between hEDS and ASD can enhance awareness and diagnosis, potentially leading to improved management strategies for affected individuals. Recognizing the comorbidity may also inform clinical approaches to treatment and care.