Haemodynamic effects of selective venoconstriction with centhaquine in spontaneously breathing patients with mixed hypovolaemic-vasodilatory shock.
Exp PhysiolSep 1, 2026 (epub)
Athanasios Chalkias, Aman Khanna, Krish Vaidya et al.
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In 30 seconds
This multicenter phase IV clinical trial investigated the effects of centhaquine on hemodynamics in 15 spontaneously breathing patients with mixed hypovolaemic-vasodilatory shock. The study found that centhaquine administration significantly increased mean circulatory filling pressure and cardiac output, with mean arterial pressure rising from 56.8 ± 1.5 to 69.8 ± 2.0 mmHg (adjusted P < 0.001).
Key findings
- Mean circulatory filling pressure increased from 6.03 ± 0.22 to 7.28 ± 0.21 mmHg (adjusted P < 0.001).
- Cardiac output rose from 5.62 ± 0.22 to 6.80 ± 0.24 L min -1 (adjusted P < 0.001).
- Mean arterial pressure increased from 56.8 ± 1.5 to 69.8 ± 2.0 mmHg (adjusted P < 0.001).
- No drug-related adverse events were observed during the study.
Why it matters
The study highlights a potential therapeutic approach for managing mixed hypovolaemic-vasodilatory shock, suggesting that selective venoconstriction with centhaquine may enhance hemodynamic stability without significant adverse effects.