Probiotics Accelerate Microbiota and Metabolic Pathway Recovery Following Colonoscopy Bowel Preparation in Ulcerative Colitis.
Xiaohan Ma, Jing Guan, Guangpeng Liu et al.
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In 30 seconds
This randomized controlled trial investigated the impact of probiotic supplementation on microbiota recovery following polyethylene glycol (PEG)-based bowel preparation in 79 participants, including 39 patients with ulcerative colitis (UC). Results indicated that probiotics significantly improved microbial diversity and evenness in UC patients, with notable enrichment of beneficial taxa such as Faecalibacterium and Blautia.
Key findings
- Probiotic supplementation improved Shannon diversity and evenness in patients with UC.
- Bowel preparation significantly reduced microbial diversity in healthy controls, with gradual recovery by day 28.
- Probiotics enriched beneficial short-chain fatty acid-producing taxa and reduced harmful Proteobacteria and Fusobacteria.
Why it matters
Understanding the effects of bowel preparation on gut microbiota is crucial for managing patients with ulcerative colitis, who are already at risk for dysbiosis. Probiotic supplementation may offer a strategy to enhance microbiota recovery and improve patient outcomes.