Delayed appearance of bilateral cerebral peduncle lesions in autoimmune glial fibrillary acidic protein astrocytopathy: A serial MRI case series.

J Neurol SciAug 27, 2026 (epub)
Case ReportNeurology

Yusuke Akitomi, Kensuke Takahashi, Yuta Komori et al.

✦ AI-curated · Sources linked

Case in brief

Three patients with autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) underwent serial MRI to assess brain lesions. Initial MRIs showed various hyperintensities but did not reveal bilateral cerebral peduncle involvement. Follow-up MRIs, conducted 31-59 days later, demonstrated T2-weighted/FLAIR hyperintensities in the bilateral cerebral peduncles in all patients, indicating a delayed manifestation of the disease.

Diagnostic / clinical pearl

Clinicians should be aware that bilateral cerebral peduncle lesions may appear as delayed MRI findings in patients with GFAP-A, necessitating careful follow-up imaging.

Source

PubMed · PMID 42679587

Published in J Neurol Sci. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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