Efficacy and safety of MR guided-laser interstitial thermal therapy versus resective surgery for MRI-positive focal cortical dysplasia type II and tuberous sclerosis complex: A systematic review and meta-analysis.
Yuxin Wang, Yuchen Tai, Tinghong Liu et al.
✦ AI-curated · Sources linked
In 30 seconds
This systematic review and meta-analysis compared the efficacy and safety of magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) and resective surgery in patients with MRI-positive focal cortical dysplasia type II (FCD II) and tuberous sclerosis complex (TSC). The analysis included 36 studies, revealing no significant difference in seizure freedom rates (0.72 vs. 0.71, P = 0.838) or complication rates (P = 0.469) between the two treatments.
Key findings
- Seizure freedom rates were similar for MRgLITT and resective surgery in the combined FCD II/TSC group (0.72 vs. 0.71, P = 0.838).
- In FCD II-only patients, seizure freedom rates were 0.74 for MRgLITT and 0.85 for resective surgery (P = 0.065).
- For TSC-only patients, seizure freedom rates were 0.50 for MRgLITT and 0.59 for resective surgery (P = 0.510).
- Complication rates did not differ significantly between MRgLITT and resective surgery (P = 0.469).
Why it matters
Understanding the comparative efficacy and safety of MRgLITT and resective surgery is crucial for clinicians managing drug-resistant epilepsy, as both treatments offer similar outcomes for patients with FCD II and TSC.