Prevalence of unruptured intracranial aneurysms according to comorbidities, risk factors, country, and time period: a systematic review and meta-analysis.
Judith Dremel, Viktoria Rücker, Camilo Badel et al.
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In 30 seconds
This systematic review and meta-analysis examined the prevalence of unruptured intracranial aneurysms (UIAs) across various comorbidities and risk factors, analyzing data from 316,131 participants. The estimated prevalence of UIAs in a reference population was 3.9%. Notably, individuals with autosomal dominant polycystic kidney disease had a prevalence of 12.8%, with an adjusted prevalence ratio of 4.4 compared to the reference population.
Key findings
- The prevalence of UIAs in individuals with atherosclerosis was 5.5%.
- For those with a positive family history of aSAH or UIA, the prevalence was 7.9%.
- Individuals with connective-tissue disorders had a UIA prevalence of 10.3%.
- The prevalence of UIAs increased from 0.7% in 2002-2015 to 1.4% in 2016-2022.
Why it matters
Understanding the prevalence of UIAs in relation to specific risk factors and comorbidities is crucial for clinicians. It can inform screening strategies and risk assessment in populations at higher risk, potentially improving patient outcomes.