The effect of vortioxetine on cognitive function in older adults with major depressive disorder: A systematic review.
J Affect DisordSep 1, 2026 (epub)
Muhammad El-Kassem, Mohamed Ali, Mohamad Tarek Madani et al.
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In 30 seconds
This systematic review evaluated the effects of vortioxetine on cognitive function and depressive symptoms in older adults (≥65 years) with major depressive disorder. The review included twelve studies and found that vortioxetine consistently reduced depressive symptoms, while cognitive effects were mixed, with some improvements in specific domains but no clear advantage over placebo or other antidepressants.
Key findings
- Vortioxetine consistently reduced depressive symptoms in older adults with major depressive disorder.
- Observational studies showed improvements in processing speed, attention, and executive function.
- Randomized studies reported inconsistent effects on global cognition compared to placebo.
- Functional outcomes suggested a modest benefit from vortioxetine treatment.
Why it matters
Understanding the cognitive effects of antidepressants like vortioxetine is crucial for managing late-life depression, as cognitive impairment can complicate treatment and affect overall patient functioning.