Dealcoholized muscadine wine improved skin elasticity and oxidative stress biomarkers without affecting gut microbiome in women over 40 in a randomized controlled trial.

In 30 seconds

This randomized controlled trial examined the effects of dealcoholized muscadine wine (DMW) on skin health and oxidative stress in 17 healthy women over 40. Participants consumed 300 mL of DMW or a placebo daily for 6 weeks. DMW significantly improved skin elasticity and reduced plasma levels of matrix metalloproteinase-9 and advanced glycation end products, while not affecting the gut microbiome.

Key findings

• DMW significantly decreased transepidermal water loss compared to placebo.
• Facial gross elasticity improved significantly with DMW intake.
• Plasma levels of matrix metalloproteinase-9 decreased with DMW compared to placebo.
• The gut microbiome's abundance, diversity, and functions were unaffected by DMW.

Why it matters

The findings suggest that polyphenol-rich dealcoholized muscadine wine may offer benefits for skin health and oxidative stress management in women over 40, potentially influencing dietary recommendations for this population.