Protective association of the ELMO1 rs741301 variant against diabetes mellitus and diabetic nephropathy: a systematic meta-analysis of case-control studies.
Ann Hum BiolSep 2, 2026 (epub)
Sheena Mariam Thomas, Anu Shibi Anilkumar, Ramakrishnan Veerabathiran
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In 30 seconds
This systematic meta-analysis evaluated the association between the ELMO1 rs741301 polymorphism and diabetic nephropathy (DN) in individuals with diabetes mellitus (DM). Analyzing nine case-control studies with 880 DM and 1008 DN participants, the results indicated a significant protective association, with an odds ratio of 0.77 under the allelic model, suggesting a reduced susceptibility to DN linked to this genetic variant.
Key findings
- The ELMO1 rs741301 polymorphism showed a protective association with DN (OR = 0.77, 95% CI: 0.67-0.88).
- Under the recessive model, the odds ratio was 0.74 (95% CI: 0.61-0.90).
- The dominant model yielded an odds ratio of 0.68 (95% CI: 0.53-0.88).
- No significant association was found under the over-dominant model.
Why it matters
Understanding genetic factors like the ELMO1 rs741301 polymorphism can enhance knowledge of diabetic complications, potentially guiding future research and therapeutic strategies in managing diabetic nephropathy.