The prevalence of frontotemporal dementia: a systematic review and meta-analysis.
Cuicui Wang, Yunpeng Zhang, Yichi Tao et al.
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In 30 seconds
This systematic review and meta-analysis estimated the global prevalence of frontotemporal dementia (FTD) in individuals under 65, analyzing 21 studies with 38,656,516 participants. The pooled prevalence was found to be 30 cases per 100,000 population (0.03%, 95% CI: 0.01% to 0.12%), highlighting significant variability across studies.
Key findings
- The pooled global prevalence of FTD was 30 cases per 100,000 population.
- Subgroup analyses indicated a significant association between prevalence and age range (P=0.01).
- No significant differences in prevalence were found by region (P=0.38) or diagnostic criteria era (P=0.28).
- Extreme heterogeneity was observed among the studies (I² = 100%).
Why it matters
Understanding the prevalence of frontotemporal dementia is crucial for healthcare planning and resource allocation, especially as it is a leading cause of early-onset dementia. This data can inform public health strategies and highlight the need for further research.
What to keep in mind
The study noted substantial variability in reported prevalence and emphasized the need for more high-quality, population-based studies.