Exploring disparities in adherence to colorectal cancer clinical practice guidelines and associated survival outcomes: a systematic review and meta-analysis.
Gobi Hariyanayagam Gunasekaran, Baharudin Ibrahim, Fahad Saleem et al.
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In 30 seconds
This systematic review and meta-analysis examined adherence to colorectal cancer clinical practice guidelines (CPGs) and its impact on survival outcomes. Analyzing 30 studies, it found that adherence was associated with a non-significant overall survival benefit (RR = 0.90; 95% CI 0.67-1.20), with significant survival advantages noted for Stage II (RR = 0.58; 95% CI 0.34-0.99) and Stage III colon cancer (RR = 0.58; 95% CI 0.41-0.80).
Key findings
- Adherence to CPGs was associated with a non-significant survival benefit (RR = 0.90; 95% CI 0.67-1.20).
- Significant survival advantages were observed for Stage II colon cancer (RR = 0.58; 95% CI 0.34-0.99).
- Stage III colon cancer also showed significant survival benefits with adherence (RR = 0.58; 95% CI 0.41-0.80).
- Non-adherence was more prevalent among older patients and those from disadvantaged backgrounds.
Why it matters
Understanding disparities in adherence to clinical practice guidelines is crucial for improving colorectal cancer outcomes. Addressing these disparities can lead to more equitable care and potentially better survival rates for high-risk populations.